Cytokine synergy, collagenases and cartilage collagen breakdown.
نویسندگان
چکیده
We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.
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عنوان ژورنال:
- Biochemical Society symposium
دوره 70 شماره
صفحات -
تاریخ انتشار 2003